Analysis of changes in sensory information processing circuits and their molecular control mechanisms during sexual maturation in C. elegans.
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- Fujiwara Manabi
- Principal Investigator
- 九州大学
About this project
- Japan Grant Number
- JP17K07503
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 17K07503
- Research Category
- Grant-in-Aid for Scientific Research (C)
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Biological Sciences > Biology > Basic biology > Genetics/Chromosome dynamics
- Research Institution
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- Kyushu University
- Project Period (FY)
- 2017-04-01 〜 2023-03-31
- Project Status
- Completed
- Budget Amount*help
- 4,940,000 Yen (Direct Cost: 3,800,000 Yen Indirect Cost: 1,140,000 Yen)
Research Abstract
In the nematode C. elegans, the proliferation of germ cells during the growth to adults causes the increase of the ability of worms to approach an odor of food (chemotaxis). Previously we have shown that the AIB neuron, which is a downstream interneuron of the olfactory neuron, changes its responsiveness to the odorant stimuli according to the proliferation of germ cells, and thus regulates the behavioral change. In this study, it was revealed that the guanylate cyclase GCY-28 is involved in the regulation of odor responsiveness of the AIB neuron, and that GCY-28 works in the AIA neuron, which connects to AIB neuron. In addition, it was revealed that the ASI chemosensory neuron, which senses pheromones and other substances, is also involved in changes in the responsiveness of AIB neuron.
Keywords
Details 詳細情報について
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- CRID
- 1040000781967032192
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- Text Lang
- ja
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- Data Source
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- KAKEN