A study of the regulatory mechanism of lymph node metastasis in oral cancer by Sprouty, tyrosine kinase inhibitor molecule.
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- Taketomi Takaharu
- Principal Investigator
- 久留米大学
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- 讃井 彰一
- Co-Investigator
- 九州大学
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- 福田 隆男
- Co-Investigator
- 九州大学
About this project
- Japan Grant Number
- JP17K11692
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 17K11692
- Research Category
- Grant-in-Aid for Scientific Research (C)
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Biological Sciences > Medicine, Dentistry, and Pharmacy > Dentistry > Pathobiological dentistry/Dental radiology
- Research Institution
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- Kurume University
- Project Period (FY)
- 2017-04-01 〜 2022-03-31
- Project Status
- Completed
- Budget Amount*help
- 4,550,000 Yen (Direct Cost: 3,500,000 Yen Indirect Cost: 1,050,000 Yen)
Research Abstract
Sprouty family members are induced by FGF rather than by EGF or TGF-β, and their function is not only to regulate signaling downstream of tyrosine kinase-type receptors but also to inhibit Smad1/5/8 phosphorylation in the TGF-β signaling pathway, which is closely related to epithelial mesenchymal transition. Phosphorylation in the TGF-β signaling pathway, which is closely related to epithelial-mesenchymal transition, and may negatively regulate epithelial-mesenchymal transition. In addition, the cysteine-rich region of the Spry domain is involved in the binding of Caveolin, which acts only in the MAP kinase pathway in Raft, suggesting that the inhibition of TGF-β signaling is Caveolin-independent.
Keywords
Details 詳細情報について
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- CRID
- 1040000781970134272
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- Text Lang
- ja
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- Data Source
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- KAKEN