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Analysis of cancer immune response to lymph node metastasis mechanism in oral squamous cell carcinoma
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- kumamaru wataru
- Principal Investigator
- 九州大学
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- 鬼丸 満穂
- Co-Investigator
- 九州大学
About This Project
- Japan Grant Number
- JP17K11876 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 17K11876
- Research Category
- Grant-in-Aid for Scientific Research (C)
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Biological Sciences > Medicine, Dentistry, and Pharmacy > Dentistry > Surgical dentistry
- Research Institution
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- Kyushu University
- Project Period (FY)
- 2017-04-01 〜 2022-03-31
- Project Status
- Completed
- Budget Amount*help
- 4,420,000 Yen (Direct Cost: 3,400,000 Yen Indirect Cost: 1,020,000 Yen)
Research Abstract
Elucidation of cancer metastasis and immune response requires considering cancer heterogeneity and diversity. It is deemed essential to analyze at the single-cell level rather than the bulk level. Therefore, after the primary culture of oral squamous epithelial cancer cells, single-cell culture was performed from the cell group preserved early to prepare 99 cells. The biological characteristics (cell proliferation ability, self-renewal ability in suspension culture) of ten of them were analyzed. The two cells were considered to be the same cell, while the other cells had different characteristics. In particular, cells with weak cell adhesion and basal cell-like cells were considered to be important cells that could not be analyzed in bulk because of their low proliferative capacity.
Keywords
Details 詳細情報について
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- CRID
- 1040000781970279936
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- Text Lang
- ja
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- Data Source
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- KAKEN