New technique for tissue regeneration with induction of immature cells by atmospheric pressure plasma
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- Kataoka Yosky
- Principal Investigator
- 国立研究開発法人理化学研究所
About this project
- Japan Grant Number
- JP17K18774
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 17K18774
- Research Category
- Grant-in-Aid for Challenging Research (Exploratory)
- Allocation Type
-
- Multi-year Fund
- Review Section / Research Field
-
- Plasma science and related fields
- Research Institution
-
- Institute of Physical and Chemical Research
- Project Period (FY)
- 2017-06-30 〜 2020-03-31
- Project Status
- Completed
- Budget Amount*help
- 6,110,000 Yen (Direct Cost: 4,700,000 Yen Indirect Cost: 1,410,000 Yen)
Research Abstract
In this study, we evaluated whether direct irradiation of atmospheric pressure plasma to the adult mammalian cerebral cortex can lead to tissue regeneration by inducing immature cells. In particular, we tried to identify the origin of those immature cells, and to observe the induction manner of immature cells after atmospheric pressure plasma irradiation to the cerebral cortex in rats, using large-scale electron microscopy which realizes comprehensive observation of the tissue microstructure in wider range exceeding a few millimeters. Furthermore, even in cerebral infarction model of rats, it was found that many cells expressing immature cell markers can be induced in the infarction area by plasma irradiation.
