Inhibitory mechanism of cell division by spatiotemporally modulated electric field and its application

KAKEN

About This Project

Japan Grant Number
JP18H03520 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
18H03520
Research Category
Grant-in-Aid for Scientific Research (B)
Allocation Type
  • Single-year Grants
Review Section / Research Field
  • Basic Section 90110:Biomedical engineering-related
Research Institution
  • Kyushu University
Project Period (FY)
2018-04-01 〜 2022-03-31
Project Status
Completed
Budget Amount*help
17,160,000 Yen (Direct Cost: 13,200,000 Yen Indirect Cost: 3,960,000 Yen)

Research Abstract

To elucidate the mechanism of inhibition of cell division by the application of an alternating electric field, experiments using eggs of Xenopus laevis and numerical simulation were conducted. The direction of cell division and cell death could be easily observed as expected. The application of an electric field caused abnormal development of eggs. In the numerical analysis, we were able to predict the effect of cell size and electrical properties on the intensity of the dielectrophoretic force generated in the cell. In addition, we showed that the Taguchi method can be used to study the effects of uncertainties in electrical properties and cell division angles on the strength of the dielectrophoretic force. The optimum condition of the electric field with a high robustness to unpredictable variations in cell size and electrical properties was identified, which would be useful for improving the efficacy of cancer treatment using weak alternating electric fields.

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