Environmental electrophiles exposome and reactive sulfur species as its regulator molecule
About This Project
- Japan Grant Number
- JP18H05293 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 18H05293
- Research Category
- Grant-in-Aid for Scientific Research (S)
- Allocation Type
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- Single-year Grants
- Review Section / Research Field
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- Broad Section K
- Research Institution
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- University of Tsukuba
- Project Period (FY)
- 2018-06-11 〜 2023-03-31
- Project Status
- Completed
- Budget Amount*help
- 195,260,000 Yen (Direct Cost: 150,200,000 Yen Indirect Cost: 45,060,000 Yen)
Research Abstract
Combined exposure of cultured cells and mice to environmental electrophiles was found to lower the activation of intracellular redox signaling and toxicity thresholds compared to single exposure. On the other hand, simultaneous exposure to reactive sulfur species that are able to capture environmental electrophiles, resulting in the formation of sulfur adducts repressed the adverse effects of environmental electrophiles. With methylmercury as a model of environmental electrophile, we also found that bismethylmercury sulfide, a sulfur adduct of methylmercury, spontaneously decomposition, leading to formation of dimethylmercury, which is excreted from the body through exhalation due to its high volatile species. Furthermore, when a variety of cells were exposed to sulfur stress, intracellular cysteine persulfide was shown to be excreted outside the cells via cystine-dependent antiporters.
Keywords
Details 詳細情報について
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- CRID
- 1040000781994827648
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- Text Lang
- ja
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- Data Source
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- KAKEN
