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Nuclear and chromatin structure dynamics and gene regulatioin
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- Kimura Hiroshi
- Principal Investigator
- 東京工業大学
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- 伊藤 由馬
- Co-Investigator
- 東京工業大学
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- 大川 恭行
- Co-Investigator
- 九州大学
About This Project
- Japan Grant Number
- JP18H05527 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 18H05527
- Research Category
- Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Allocation Type
-
- Single-year Grants
- Review Section / Research Field
-
- Biological Sciences
- Research Institution
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- Tokyo Institute of Technology
- Project Period (FY)
- 2018-06-29 〜 2023-03-31
- Project Status
- Completed
- Budget Amount*help
- 235,690,000 Yen (Direct Cost: 181,300,000 Yen Indirect Cost: 54,390,000 Yen)
Research Abstract
This research aimed to elucidate the function of chromatin structure through histone modifications from the perspective of transcriptional activation potential. Through live-cell imaging of zebrafish embryos, we revealed that histone acetylation enhances the potential for transcriptional activation. We also developed genetically encoded single-stranded variable region antibody probes that specifically recognize phosphorylation of RNA polymerase II at the transcription initiation and elongation stages. Based on the distinct localization and dynamics of transcription initiation and elongation foci in living cells, a model of transcription organization was proposed. In addition, we have developed low-input epigenome analysis techniques.
Details 詳細情報について
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- CRID
- 1040000781994964992
-
- Text Lang
- ja
-
- Data Source
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- KAKEN
- IRDB