Elucidation of chromatin regulation by nuclear RNA bodies
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- SAITOH Noriko
- Principal Investigator
- 公益財団法人がん研究会
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- 落合 博
- Co-Investigator
- 広島大学
About this project
- Japan Grant Number
- JP18H05531
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 18H05531
- Research Category
- Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Allocation Type
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- Single-year Grants
- Review Section / Research Field
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- Biological Sciences
- Research Institution
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- Japanese Foundation for Cancer Research
- Project Period (FY)
- 2018-06-29 〜 2023-03-31
- Project Status
- Completed
- Budget Amount*help
- 129,350,000 Yen (Direct Cost: 99,500,000 Yen Indirect Cost: 29,850,000 Yen)
Research Abstract
In the cell nucleus, many RNA bodies are formed based on non-coding RNAs that are act as "seeds." This study revealed the molecular mechanisms of the ELEANOR RNA cloud formed in the nucleus of hormone-dependent breast cancer cells. It also focused on the nucleolus which is the largest nuclear RNA body. Specifically, we have elucidated that, in breast cancer, the ELEANOR non-coding RNAs regulate transcription of multiple genes within the ELEANOR-TAD (topologically associated domains) that is a mega base-scale chromatin domain. ELEANOR also mediates long-range chromatin interactions to equilibrate between cancer cell proliferation and apoptosis.
Details 詳細情報について
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- CRID
- 1040000781994966272
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- Text Lang
- ja
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- Data Source
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- KAKEN