Effect of osteocalcin on sarcopenic obesity
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- Mizokami Akiko
- Principal Investigator
- 九州大学
About this project
- Japan Grant Number
- JP18K09521
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 18K09521
- Research Category
- Grant-in-Aid for Scientific Research (C)
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Basic Section 57010:Oral biological science-related
- Research Institution
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- Kyushu University
- Project Period (FY)
- 2018-04-01 〜 2022-03-31
- Project Status
- Completed
- Budget Amount*help
- 4,550,000 Yen (Direct Cost: 3,500,000 Yen Indirect Cost: 1,050,000 Yen)
Research Abstract
Uncarboxylated osteocalcin (GluOC) is a bone-derived hormone that plays an important role not only in glucose and energy metabolism but also in maintaining skeletal muscle mass. GPRC6A, a member of family C of G protein-coupled receptors, has been reported to serve as a GluOC receptor. We analyzed adipocyte-specific GPRC6A deficient mice and found that these animals manifested adipocyte hypertrophy under obesogenic environment. This was associated with reduced lipolytic activity due to down-regulation of lipolytic enzymes in adipose tissue of the knockout mice. Suppressed lipolysis resulted in reduced fatty acid release in the circulation compared with control mice. Our results suggest that the constitutive activation of GPRC6A signaling by GluOC in adipocytes plays a key role in lipolysis, providing fatty acid as an energy source to the skeletal muscle.
Details 詳細情報について
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- CRID
- 1040000782001351040
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- Text Lang
- ja
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- Data Source
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- KAKEN