Investigation pf a novel sterilisation method by peroxynitric acid for peri-implant infection

About This Project

Japan Grant Number
JP18K09685 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
18K09685
Research Category
Grant-in-Aid for Scientific Research (C)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Basic Section 57050:Prosthodontics-related
Research Institution
  • Kyushu University
Project Period (FY)
2018-04-01 〜 2022-03-31
Project Status
Completed
Budget Amount*help
4,290,000 Yen (Direct Cost: 3,300,000 Yen Indirect Cost: 990,000 Yen)

Research Abstract

This research evaluated the bactericidal effects of peroxynitric acid (HOONO2; PNA) on biofilms formed on titanium surfaces. Streptococcus gordonii was cultured on titanium discs that were then used to evaluate the bactericidal effects of PNA. Using low concentration of PNA, the bacterial count based on a CFU assay reached an undetectable level within 10 s.Bacillus subtilis solution was coated on the dental model, and impression taking of the model was done by dental impression material. Dental impression material was disinfected by PNA, and bactericidal effects were evaluated. The bacterial count based on a CFU assay reached an undetectable level within 10 minutes. PNA is useful for sterilizing biofilms on titanium surfaces and dental impression material that have been contaminated with bacteria.

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