Detection of Microvascular Collaterals in Ischemic Myocardium Using Ultra-high-resolution CT
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- Kojima Tsukasa
- Principal Investigator
- 九州大学
About this project
- Japan Grant Number
- JP18K15552
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 18K15552
- Research Category
- Grant-in-Aid for Early-Career Scientists
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Basic Section 52040:Radiological sciences-related
- Research Institution
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- Kyushu University
- Project Period (FY)
- 2018-04-01 〜 2023-03-31
- Project Status
- Completed
- Budget Amount*help
- 3,510,000 Yen (Direct Cost: 2,700,000 Yen Indirect Cost: 810,000 Yen)
Research Abstract
This study determined the maximum heart rate for feasible coronary CT imaging using ultra-high-resolution CT (UHRCT) while maintaining high spatial resolution, aiming to visualize microvascular collaterals in ischemic myocardium. Through experiments with a cardiac motion phantom, simulated coronary arteries, and analysis of clinical images, UHRCT's high spatial resolution was confirmed up to 60 bpm. Subsequent analysis of clinical images from patients below 60 bpm demonstrated UHRCT's ability to visualize previously undetectable microvascular collaterals. These findings suggest the potential of next-generation CT scanner like Photon Counting CT, which offer superior noise reduction and spatial resolution, in more visualizing microvascular collaterals in ischemic myocardium.