4,160,000 Yen
(Direct Cost: 3,200,000 Yen Indirect Cost: 960,000 Yen)
Research Abstract
Defects in the maxillofacial region are severe and complex. Implants are applied as a structural base for maxillofacial prostheses; however, the success rate of maxillofacial implants is currently low.
This study focused on the soft tissue around implants that penetrate the oral mucosa and skin. Epithelial and fibroblast cells from rat oral mucosa and back skin were collected and cultured on titanium plates. The maxillary first molars of rats were extracted, and experimental implants were placed.
Evaluation of peri-implant soft tissue sealing revealed that the predominant surface properties differed between the epithelium and connective tissue. Additionally, the soft tissue sealing ability around implants was found to be inferior to that of natural teeth. These findings suggest that improvement in the surface properties of the implant and the soft tissue sealing ability may affect the success of implant treatment.
