Design and synthesis of calcium ion regulatory molecules based on maitotoxin

About this project

Japan Grant Number
JP19H02720
Funding Program
Grants-in-Aid for Scientific Research
Funding organization
Japan Society for the Promotion of Science
Project/Area Number
19H02720
Research Category
Grant-in-Aid for Scientific Research (B)
Allocation Type
  • Single-year Grants
Review Section / Research Field
  • Basic Section 33020:Synthetic organic chemistry-related
Research Institution
  • Kyushu University
Project Period (FY)
2019-04-01 〜 2022-03-31
Project Status
Completed
Budget Amount*help
17,550,000 Yen (Direct Cost: 13,500,000 Yen Indirect Cost: 4,050,000 Yen)

Research Abstract

本研究では,(1)MTXの疎水性部分に相当するW-F’環部(1)を化学合成し,MTXによって引き起こされるCa2+流入活性を阻害するかどうかを明らかにする。また,(2)MTXの疎水性部分に相当するG-U環部(2)を化学合成し,MTXと同等なCa2+流入活性を発現するかどうかを明らかにする。

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