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Biological activities of water-soluble free oligosaccharides obtained from edible beans and their applications.
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- KIMURA Mariko
- Principal Investigator
- 神戸女子大学
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- NAGASAWA Haruko
- Research Collaborator
- 神戸女子大学
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- MAEDA Megumi
- Research Collaborator
- 岡山大学
About This Project
- Japan Grant Number
- JP23500944 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 23500944
- Research Category
- Grant-in-Aid for Scientific Research (C)
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Integrated Science and Innovative Science > Comprehensive Fields > Human life science > Eating habits, studies on eating habits
- Research Institution
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- Kobe Women's University
- Kurashiki Sakuyo University
- Project Period (FY)
- 2011-04-28 〜 2016-03-31
- Project Status
- Completed
- Budget Amount*help
- 5,200,000 Yen (Direct Cost: 4,000,000 Yen Indirect Cost: 1,200,000 Yen)
Research Abstract
In this study, we analyzed functional and structural features of free oligo- saccharides prepared from Zatsu mame (defined as edible beans other than soybean and peanut in Japanese) to find out good sources of latent bioactive oligosaccharides. At first, we prepared several kinds of glycopeptides and oligosaccharide fractions from Adzuki and Tebo by a combination of cation exchange chromatography and gel filtration. Using bean glycopeptides and γ-polyglutamic acid, we developed a novel glyco-polymer bearing several hundreds of oligosaccharides and assayed stimulating activity to antigen presentation cells, T-cell proliferation, and production of cytokines. Prebiotic activities of the bean-oligosaccharides on growth of bifidobacteria and lactobacilii were determined by measuring the number of these bacteria, suggesting that Adzuki and Tebo contain prebio-active oligosaccharides or glycopeptides.
