Towards better understanding of the molecular mechanisms of functional diversity of the electrogenic sodium bicarbonate cotransporter

KAKEN

About This Project

Japan Grant Number
JP24659094 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
24659094
Research Category
Grant-in-Aid for Challenging Exploratory Research
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Biological Sciences > Medicine, Dentistry, and Pharmacy > Basic medicine > General physiology
Research Institution
  • Obihiro University of Agriculture and Veterinary Medicine
Project Period (FY)
2012-04-01 〜 2016-03-31
Project Status
Completed
Budget Amount*help
4,030,000 Yen (Direct Cost: 3,100,000 Yen Indirect Cost: 930,000 Yen)

Research Abstract

The main aim of this project was to gain some clues as to the cellular and molecular mechanisms of functional diversity of the electrogenic sodium bicarbonate cotransporter NBCe1-B observed in various native tissues and cell types. Using a heterologous mammalian expression system, H+ was suggested to be a cytosolic factor that might modify the intracellular Mg2+-sensitivity of NBCe1-B. Studies on ion channels in bovine parotid acinar cells endogenously expressing NBCe1-B may raise the possibilities that pH-sensitive K+ currents and TRPM6/7-like cation channel activity might be involved, at least in part, in regulation of NBCe1-B in these cells. The data obtained in this project will be useful for future studies to better understand regulatory mechanisms of the electrogenic sodium bicarbonate cotransporter activity in intact cells.

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