Innovative Therapies Targeting Increased Susceptibility to Chemoradiotherapy for Esophageal Cancer

About This Project

Japan Grant Number
JP20K09105 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
20K09105
Research Category
Grant-in-Aid for Scientific Research (C)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Basic Section 55020:Digestive surgery-related
Research Institution
  • National Hospital Organization, Kyushu Cancer Center
Project Period (FY)
2020-04-01 〜 2023-03-31
Project Status
Completed
Budget Amount*help
4,290,000 Yen (Direct Cost: 3,300,000 Yen Indirect Cost: 990,000 Yen)

Research Abstract

食道扁平上皮癌の化学放射線療法感受性に関与する相互組換え修復の主要因子であるRad51発現を調節するE2F1/Rb-CDK4/6/Cyclin D1経路に着目し、CDK4/6阻害薬による化学放射線療法の感受性の改善効果を検討する。

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