Macrophage immune checkpoint dual mechanism in pancreatic cancer

KAKEN

About This Project

Japan Grant Number
JP21K08779 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
21K08779
Research Category
Grant-in-Aid for Scientific Research (C)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Basic Section 55020:Digestive surgery-related
Research Institution
  • Kyushu University
  • Ehime University
Project Period (FY)
2021-04-01 〜 2024-03-31
Project Status
Completed
Budget Amount*help
4,160,000 Yen (Direct Cost: 3,200,000 Yen Indirect Cost: 960,000 Yen)

Research Abstract

膵癌における有効なマクロファージ免疫チェックポイント分子やその作用機序は殆ど解明されていない。そこで"Don't eat me" signal と"Eat me" signalのdual mechnismをもつマクロファージ免疫チェックポイントによる膵癌微小免疫環境の維持機構を解明する。腫瘍内マクロファージを中心とした免疫監視機構の制御により、抗腫瘍効果を回復させる新規免疫療法の確立を目指す。

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