Design and systematic synthesis of novel metal-organic polyhedra for controlled integration with enzymes

KAKEN

About This Project

Japan Grant Number
JP24K08447 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
24K08447
Research Category
Grant-in-Aid for Scientific Research (C)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Basic Section 34010:Inorganic/coordination chemistry-related
Research Institution
  • Kyushu University
Project Period (FY)
2024-04-01 〜 2027-03-31
Project Status
Granted
Budget Amount*help
4,550,000 Yen (Direct Cost: 3,500,000 Yen Indirect Cost: 1,050,000 Yen)

Research Abstract

本課題では、簡便かつ極めて温和な条件で運用可能な「水溶性金属－有機多面体（MOP）を用いた酵素固定化法」を様々な酵素に適用できる技術に成熟させて、酵素固定化法として一般化する。更に、配位子修飾によるMOP表面の設計、MOP-酵素間相互作用の解明およびMOP-酵素複合体の最適化により、異なるスケールの観点から研究を展開し、特定の酵素に対するMOPのカスタムメイド設計指針の確立を目指す。

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