Conceptualization of mesenchymal stem cell-related diseases and elucidation of their etiology and treatment modality

About this project

Japan Grant Number
JP23K27782
Funding Program
Grants-in-Aid for Scientific Research
Funding organization
Japan Society for the Promotion of Science
Project/Area Number
23K27782
Research Category
Grant-in-Aid for Scientific Research (B)
Allocation Type
  • Multi-year Fund
  • Single-year Grants
Review Section / Research Field
  • Basic Section 57050:Prosthodontics-related
Research Institution
  • Kyushu University
Project Period (FY)
2023-04-01 〜 2027-03-31
Project Status
Granted
Budget Amount*help
18,460,000 Yen (Direct Cost: 14,200,000 Yen Indirect Cost: 4,260,000 Yen)

Research Abstract

間葉系幹細胞(MSC)は種々の疾患の治療能力を有していることが明らかになりつつある.一方で,一部の疾患において「MSCの劣化」が症状増悪の一端を担っていると仮定しうる状況も見られるようになってきた.本研究ではこれを「間葉系幹細胞関連疾患」と定義し,疾患治療のターゲットを「劣化MSCの治療」に置くという視点を提示したい.そのために,まずMSCの疾患治療能力の謎を解明し,劣化MSCの機能改善・向上を通して新規治療法や創薬に結びつけることを目標とする.

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