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Discovery of novel Nav1.7 inhibitors by using bioinformatics
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- Kawamata Mikito
- Principal Investigator
- 信州大学
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- 山田 充彦
- Co-Investigator
- 信州大学
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- 上園 保仁
- Co-Investigator
- 国立研究開発法人国立がん研究センター
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- 石田 高志
- Co-Investigator
- 信州大学
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- 木村 忠史
- Co-Investigator
- 国立研究開発法人産業技術総合研究所
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- 杉山 由紀
- Co-Investigator
- 信州大学
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- Ueda Hiroshi
- Research Collaborator
- 長崎大学
About This Project
- Japan Grant Number
- JP15H02562 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 15H02562
- Research Category
- Grant-in-Aid for Scientific Research (A)
- Allocation Type
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- Single-year Grants
- Review Section / Research Field
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- Biological Sciences > Medicine, Dentistry, and Pharmacy > Clinical surgery > Anesthesiology
- Research Institution
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- Shinshu University
- Project Period (FY)
- 2015-04-01 〜 2019-03-31
- Project Status
- Completed
- Budget Amount*help
- 41,080,000 Yen (Direct Cost: 31,600,000 Yen Indirect Cost: 9,480,000 Yen)
Research Abstract
A novel missense mutation of SCN9A, a gene of Nav1.7 causes congenital insensitivity to pain (CIP) in a family. When this Nav1.7 mutation was expressed in cultured cells, the Ramp current generated upon gradual depolarization was significantly reduced in the cells. The expression of Nav1.7 was significantly lower in the mutant cells than that in the wild type cells. The Nav1.7 mutation mice mimic the features of CIP in the family,
Keywords
Details 詳細情報について
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- CRID
- 1040282256802733312
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- Text Lang
- ja
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- Data Source
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- KAKEN
