Generation of antibodies that recognize cancer-associated core fucosylation in glycoproteins

KAKEN
  • Okuda Tetsuya
    Principal Investigator
    国立研究開発法人産業技術総合研究所

About This Project

Japan Grant Number
JP15K15201 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
15K15201
Research Category
Grant-in-Aid for Challenging Exploratory Research
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Biological Sciences > Medicine, Dentistry, and Pharmacy > Boundary medicine > Laboratory medicine
Research Institution
  • National Institute of Advanced Industrial Science and Technology
Project Period (FY)
2015-04-01 〜 2018-03-31
Project Status
Completed
Budget Amount*help
3,770,000 Yen (Direct Cost: 2,900,000 Yen Indirect Cost: 870,000 Yen)

Research Abstract

To obtain monoclonal antibodies that recognize cancer-associated core fucosylation in glycoproteins, we examined application of our established immunity inducing method using artificial glycosphingolipid as immunogen. Particularly in this project, we have prepared two species of core fucosylated artificial glycosphingolipids and developed a screening method for obtaining the anti-core fucosylated glycoprotein antibody. On the other hand, we have obtained a monoclonal anti-glycosphingolipid IgG and found new activity of specific inhibitors for cellular β-hexosaminidases in this project.

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