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Sex spectrum specified by sex steroids
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- Morohashi Ken-ichirou
- Principal Investigator
- 九州大学
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- 馬場 崇
- Co-Investigator
- 九州大学
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- 今井 祐記
- Co-Investigator
- 愛媛大学
About This Project
- Japan Grant Number
- JP17H06427 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 17H06427
- Research Category
- Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Allocation Type
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- Single-year Grants
- Review Section / Research Field
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- Biological Sciences
- Research Institution
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- Kyushu University
- Project Period (FY)
- 2017-06-30 〜 2022-03-31
- Project Status
- Completed
- Budget Amount*help
- 150,150,000 Yen (Direct Cost: 115,500,000 Yen Indirect Cost: 34,650,000 Yen)
Research Abstract
Adrenal cortex of rodent displays female-biased size. In this study, we investigated the mechanism to develop the sexually different adrenal cortex. This study showed that most of gene expressions was higher in female by approximately 2-folds. Moreover, activities for energy metabolism and glucocorticoid production were increased in female. It has been known that glucocorticoid decreased skeletal muscle size though its catabolic activity. Then, we studied the effect of the sexually different adrenal cortex on the skeletal muscles, and found that the sex difference of the skeletal muscle is, at least in part, due to the adrenocortical sex difference. This study uncovered a new mechanism of sex differentiation in which androgen indirectly induces sex difference through establishing the female-biased adrenocortical functions.
Details 詳細情報について
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- CRID
- 1040282256936431232
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- Text Lang
- ja
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- Data Source
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- KAKEN