Biomarker of radiation sensitivity for precision genomic medicine in stereotactic radiotherapy for lung cancer
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- OHGA SAIJI
- Principal Investigator
- 独立行政法人国立病院機構九州医療センター(臨床研究センター)
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- 神谷 武志
- Co-Investigator
- 九州大学
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- 浅山 良樹
- Co-Investigator
- 九州大学
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- 吉武 忠正
- Co-Investigator
- 九州大学
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- 浅井 佳央里
- Co-Investigator
- 九州大学
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- 本田 浩
- Co-Investigator
- 九州大学
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- 野元 諭
- Co-Investigator
- 九州大学
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- 平田 秀成
- Co-Investigator
- 九州大学
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- 塩山 善之
- Co-Investigator
- 九州大学
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- 高木 正統
- Co-Investigator
- 独立行政法人国立病院機構九州医療センター(臨床研究センター)
About this project
- Japan Grant Number
- JP17K10482
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 17K10482
- Research Category
- Grant-in-Aid for Scientific Research (C)
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Biological Sciences > Medicine, Dentistry, and Pharmacy > Clinical internal medicine > Radiation science
- Research Institution
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- National Hospital Organization, Kyushu Medical Center (Clinical Institute)
- Kyushu University
- Project Period (FY)
- 2017-04-01 〜 2022-03-31
- Project Status
- Completed
- Budget Amount*help
- 4,550,000 Yen (Direct Cost: 3,500,000 Yen Indirect Cost: 1,050,000 Yen)
Research Abstract
We analyzed the association between abnormal gene and treatment outcomes in 4 patients who treated by stereotactic radiotherapy for stage I lung cancer. However, there were no recurrence of all patients. Therefore, we analyzed the associations between gene expression and radiation sensitivity by using public data of gene expression of lung cancer cell line and report data of radiation sensitivity. G2/M checkpoint related gene and transcription related factor E2F gene were suppressed significantly in radiation resistant lung adenocarcinoma. However, there were no significant factors in lung squamous cell carcinoma.
Keywords
Details 詳細情報について
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- CRID
- 1040282256945883008
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- Text Lang
- ja
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- Data Source
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- KAKEN