Development of novel synthesizing treatment strategy by exhaustive research on temporal bone squamous cell carcinoma
About this project
- Japan Grant Number
- JP18H02951
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 18H02951
- Research Category
- Grant-in-Aid for Scientific Research (B)
- Allocation Type
-
- Single-year Grants
- Review Section / Research Field
-
- Basic Section 56050:Otorhinolaryngology-related
- Research Institution
-
- Kyushu University
- Project Period (FY)
- 2018-04-01 〜 2023-03-31
- Project Status
- Completed
- Budget Amount*help
- 17,420,000 Yen (Direct Cost: 13,400,000 Yen Indirect Cost: 4,020,000 Yen)
Research Abstract
In this study, we will attempt to identify prognostic factors and candidate genes involved in carcinogenesis and cancer progression using clinical statistical analysis combined with microsurgical anatomy analysis and an exhaustive genetic analysis. In the clinical statistical analysis, we found that middle ear extension is not a poor prognostic factor, but destruction of the ossicles is a poor prognostic marker. Furthermore, extension to the pterygoid muscle, dura mater of the posterior cranial fossa, and sigmoid sinus were found to be important poor prognostic factors. In addition, the systemic inflammatory markers were significantly correlated with poor prognosis. In addition, TP53, CDKN2A, NOTCH1, FAT1, FAT3, and NOTCH2 were detected as driver gene mutations in the comprehensive genetic analysis. The our study also found that ZDHHC11B and TARP may be genes overexpressed by DNA copy number amplification and involved in the progression of external auditory canal carcinoma.