Control of pharmacokinetic behaviors of self-assembly-based hollow nanocapsules by tuning of the physical properties of their fillings

About this project

Japan Grant Number
JP18H03534
Funding Program
Grants-in-Aid for Scientific Research
Funding organization
Japan Society for the Promotion of Science
Project/Area Number
18H03534
Research Category
Grant-in-Aid for Scientific Research (B)
Allocation Type
  • Single-year Grants
Review Section / Research Field
  • Basic Section 90120:Biomaterials-related
Research Institution
  • Kyushu University
Project Period (FY)
2018-04-01 〜 2022-03-31
Project Status
Completed
Budget Amount*help
17,030,000 Yen (Direct Cost: 13,100,000 Yen Indirect Cost: 3,930,000 Yen)

Research Abstract

In this study, we focused on the polyion complex (PIC) vesicle PICsome. First, we evaluated the modulation of physical properties by combining cross-linking and chemical modification. In particular, the benefits of silica hybrids in PIC membranes were clarified. In this process, vesicles could be prepared with anionic antimicrobials using guanidinium-functionality-containing polycationes and were useful as an antimicrobial drug delivery system. While investigating the properties of protein-containing vesicles, we discovered the world's first method for fabricating yolk-shell PIC, composed of a unilamellar PICsome and a protein-enriched core and multilamellar PICsomes. In addition, we found that sulfobetaine polymers have excellent permeability through mucosal tissues.

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