Control of pharmacokinetic behaviors of self-assembly-based hollow nanocapsules by tuning of the physical properties of their fillings
-
- Kishimura Akihiro
- Principal Investigator
- 九州大学
About this project
- Japan Grant Number
- JP18H03534
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 18H03534
- Research Category
- Grant-in-Aid for Scientific Research (B)
- Allocation Type
-
- Single-year Grants
- Review Section / Research Field
-
- Basic Section 90120:Biomaterials-related
- Research Institution
-
- Kyushu University
- Project Period (FY)
- 2018-04-01 〜 2022-03-31
- Project Status
- Completed
- Budget Amount*help
- 17,030,000 Yen (Direct Cost: 13,100,000 Yen Indirect Cost: 3,930,000 Yen)
Research Abstract
In this study, we focused on the polyion complex (PIC) vesicle PICsome. First, we evaluated the modulation of physical properties by combining cross-linking and chemical modification. In particular, the benefits of silica hybrids in PIC membranes were clarified. In this process, vesicles could be prepared with anionic antimicrobials using guanidinium-functionality-containing polycationes and were useful as an antimicrobial drug delivery system. While investigating the properties of protein-containing vesicles, we discovered the world's first method for fabricating yolk-shell PIC, composed of a unilamellar PICsome and a protein-enriched core and multilamellar PICsomes. In addition, we found that sulfobetaine polymers have excellent permeability through mucosal tissues.
Keywords
Details 詳細情報について
-
- CRID
- 1040282256970616576
-
- Text Lang
- ja
-
- Data Source
-
- KAKEN