Therapeutic effects of TNF-a inhibitors on memory impairment after cardiopulmonary arrest resuscitation
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- Wakasaki Rumie
- Principal Investigator
- 福岡大学
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- 山浦 健
- Co-Investigator
- 九州大学
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- 根本 隆行
- Co-Investigator
- 福岡大学
About this project
- Japan Grant Number
- JP18K08930
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 18K08930
- Research Category
- Grant-in-Aid for Scientific Research (C)
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Basic Section 55060:Emergency medicine-related
- Research Institution
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- Fukuoka University
- Project Period (FY)
- 2018-04-01 〜 2024-03-31
- Project Status
- Completed
- Budget Amount*help
- 4,550,000 Yen (Direct Cost: 3,500,000 Yen Indirect Cost: 1,050,000 Yen)
Research Abstract
While the rate of cardiopulmonary resuscitation of patients suffering from cardiopulmonary arrest has improved, it has become a serious problem that post-resuscitation patients develop organ damage such as encephalopathy and renal failure. The pathogenesis of these diseases is still unclear, and at present no effective treatment method has been established. It has been suggested that activation of inflammatory cells caused by cardiopulmonary resuscitation may induce cell death in various organs, but the detailed mechanism is unknown. In this study, we revealed that activation of inflammatory cells after cardiopulmonary resuscitation or ischemia-reperfusion is dependent on Ca 2+ signals with relevant cells.
