Objective evaluation and molecular mechanism of citric acid's effect on fatigue alleviation focusing on GADD34
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- Watanabe Nakamichi
- Principal Investigator
- 昭和女子大学
About this project
- Japan Grant Number
- JP18K11030
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 18K11030
- Research Category
- Grant-in-Aid for Scientific Research (C)
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Basic Section 59040:Nutrition science and health science-related
- Research Institution
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- Showa Women's University
- Project Period (FY)
- 2018-04-01 〜 2022-03-31
- Project Status
- Completed
- Budget Amount*help
- 4,420,000 Yen (Direct Cost: 3,400,000 Yen Indirect Cost: 1,020,000 Yen)
Research Abstract
We attempted to elucidate the still unknown effect of citric acid on reducing fatigue and its mechanism by using two models: a model in which mice are subjected to fatigue by swimming for 1 hour after administration of a food ingredient and a model in which mice are subjected to fatigue immediately after forced swimming and the degree of fatigue afterwards is evaluated over time. As a result of verifying the effect of citric acid in the above two models, citric acid was found to reduce fatigue, but not to restore fatigue. The results also showed that GADD34 was not involved in the fatigue-reducing effect of citric acid.
Details 詳細情報について
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- CRID
- 1040282256978975744
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- Text Lang
- ja
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- Data Source
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- KAKEN
