Overview of the regulation of skeletal muscle metabolism based on comprehensive molecular quantification
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- Matsuzaki Fumiko
- Principal Investigator
- 九州大学
About this project
- Japan Grant Number
- JP18K15011
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 18K15011
- Research Category
- Grant-in-Aid for Early-Career Scientists
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Basic Section 48020:Physiology-related
- Research Institution
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- Kyushu University
- Project Period (FY)
- 2018-04-01 〜 2023-03-31
- Project Status
- Completed
- Budget Amount*help
- 4,160,000 Yen (Direct Cost: 3,200,000 Yen Indirect Cost: 960,000 Yen)
Research Abstract
In this project, skeletal muscle composition was analyzed in terms of molecular concentration/proportion, and their temporal variation over four hours after insulin administration. A molecular interaction network consisting of approximately 10,000 insulin-responsive molecules (nodes) was constructed based on this analysis. This network illustrates about 20,000 interactions (edges) among metabolites, RNAs, and proteins that changed in their phosphorylation or expression levels. Such a comprehensive analysis provided an overview of major regulatory processes within skeletal muscles in response to insulin. Our investigation model enabled the design of scalable methods that could integrate multiple sources to characterize and visualize biologically relevant molecular interactions.
Details 詳細情報について
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- CRID
- 1040282256980842240
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- Text Lang
- ja
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- Data Source
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- KAKEN