Genetic and functional analysis of dental pulp stem cells derived from patients diagnosed with hypoganglionosis aiming for autologous cell transplantation
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- Yoshimaru Koichiro
- Principal Investigator
- 九州大学
About this project
- Japan Grant Number
- JP18K16260
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 18K16260
- Research Category
- Grant-in-Aid for Early-Career Scientists
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
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- Kyushu University
- Project Period (FY)
- 2018-04-01 〜 2022-03-31
- Project Status
- Completed
- Budget Amount*help
- 4,160,000 Yen (Direct Cost: 3,200,000 Yen Indirect Cost: 960,000 Yen)
Research Abstract
<Characteristics of stem cells derived from hypoganglionois> The proliferation ability and differentiation ability were the same as that of stem cells derived from healthy children. <Examination of stem cell transplantation> As an examination of the transplantation effect of patient-derived dental pulp stem cells on disease model mice, the observation of the body weight gain after transplantation was finished. Results such as weight gain, changes in intestinal movement, and microscopic changes were obtained. Weight gain was also observed in the patient-derived stem cell transplant group, and intestinal peristalsis showed an improving tendency electrophysiologically. Further analysis will be conducted in the future.
Keywords
Details 詳細情報について
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- CRID
- 1040282256981400448
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- Text Lang
- ja
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- Data Source
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- KAKEN