The elucidation of osteoporosis treatment targeting RNA-binding protein Musashi2 in osteoclast
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- Fujiwara Toshifumi
- Principal Investigator
- 九州大学
About this project
- Japan Grant Number
- JP18K16626
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 18K16626
- Research Category
- Grant-in-Aid for Early-Career Scientists
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Basic Section 56020:Orthopedics-related
- Research Institution
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- Kyushu University
- Project Period (FY)
- 2018-04-01 〜 2023-03-31
- Project Status
- Completed
- Budget Amount*help
- 4,160,000 Yen (Direct Cost: 3,200,000 Yen Indirect Cost: 960,000 Yen)
Research Abstract
During osteoclast differentiation, expression of the RNA-binding protein Musashi (Msi) is increased, and cell survival is regulated by Notch signaling, Notch2 and Hes1. Msi has 1 and 2 isoforms, and it is necessary to evaluate the function of both Msi1 and Msi2 in osteoclasts. Msi1 and 2 knockout mice were generated by LysM-Cre mice that selectively knockout (cKO) from monocytic cells with Msi1 and 2 Flox mice. Bone mass in the lumbar spine and femur was analyzed by micro-CT at 2 months age in 5 male and female control (Con) and 5 cKO mice, each. There was no significant difference.
Details 詳細情報について
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- CRID
- 1040282256981572480
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- Text Lang
- ja
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- Data Source
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- KAKEN
