New therapy targets for IgG4-RD and other human autoimmune disease focused on clonal expanded T and B cells.
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- MAEHARA TAKASHI
- Principal Investigator
- 九州大学
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- 中村 誠司
- Co-Investigator
- 九州大学
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- 新納 宏昭
- Co-Investigator
- 九州大学
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- 山元 英崇
- Co-Investigator
- 九州大学
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- 森山 雅文
- Co-Investigator
- 九州大学
About this project
- Japan Grant Number
- JP18KK0260
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 18KK0260
- Research Category
- Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Medium-sized Section 57:Oral science and related fields
- Research Institution
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- Kyushu University
- Project Period (FY)
- 2018-10-09 〜 2023-03-31
- Project Status
- Completed
- Budget Amount*help
- 17,940,000 Yen (Direct Cost: 13,800,000 Yen Indirect Cost: 4,140,000 Yen)
Research Abstract
IgG4-related disease (IgG4-RD) is a disease characterized by systemic organ involvement, T- and B-cell infiltration of affected organs, and specific immunoglobulin class switching (mainly IgG4). In this study, we identified IL10+IL21+LAG3+Tfh cells involved in the specific class switching of IgG4-RD by single-cell gene expression analysis of T cells infiltrating affected organs with IgG4-RD. We also found that many of the class-switched B cells expressing AID also express high levels of IL10 and IL21 receptors.
Keywords
Details 詳細情報について
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- CRID
- 1040282256983311872
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- Text Lang
- ja
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- Data Source
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- KAKEN