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Molecular patho-epidemiological study on the etiological background for oral superficial carcinoma among Asian ethnic groups
About This Project
- Japan Grant Number
- JP25305035 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 25305035
- Research Category
- Grant-in-Aid for Scientific Research (B)
- Allocation Type
-
- Partial Multi-year Fund
- Review Section / Research Field
-
- Biological Sciences > Medicine, Dentistry, and Pharmacy > Dentistry > Morphological basic dentistry
- Research Institution
-
- Niigata University
- Project Period (FY)
- 2013-04-01 〜 2017-03-31
- Project Status
- Completed
- Budget Amount*help
- 18,200,000 Yen (Direct Cost: 14,000,000 Yen Indirect Cost: 4,200,000 Yen)
Research Abstract
To investigate the epidemiological and biological backgrounds for the occurrence of oral superficial carcinomas, which are recently increasing in number in Japan with an aging population, we collected those cases from several Asian countries as controls. We firstly established a science/evidence-based standard for histopathological diagnosis of oral superficial carcinomas, with which we eliminated diagnostic disparities among hospitals from those countries. As a result, we confirmed that our new diagnostic standard based on combined expressions of some particular molecules was useful for any cases whose ethnic and etiological backgrounds were obviously different from each other. Hence, we were successful in demonstrating the diagnostic standard certainly worked in any occasions. Among the expressions of the particular molecules, those of keratin 17 were shown by our cell machinery investigations to characterize dyskeratotic carcinoma cells, which mimicked epidermal orthokeratosis.
Details 詳細情報について
-
- CRID
- 1040282257224047744
-
- Text Lang
- ja
-
- Data Source
-
- KAKEN
