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Analysis for the effects of Streptococcus pneumoniae on the exacerbation of pneumonia in RSV-infected mice compared with a brominated flame retardant
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- Watanabe Wataru
- Principal Investigator
- 九州保健福祉大学
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- 明石 敏
- Co-Investigator
- 九州保健福祉大学
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- 黒川 昌彦
- Co-Investigator
- 九州保健福祉大学
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- 吉田 裕樹
- Co-Investigator
- 九州保健福祉大学
About This Project
- Japan Grant Number
- JP26460183 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 26460183
- Research Category
- Grant-in-Aid for Scientific Research (C)
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- Biological Sciences > Medicine, Dentistry, and Pharmacy > Pharmacy > Environmental and hygienic pharmacy
- Research Institution
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- Kyushu University of Health and Welfare
- Project Period (FY)
- 2014-04-01 〜 2017-03-31
- Project Status
- Completed
- Budget Amount*help
- 4,810,000 Yen (Direct Cost: 3,700,000 Yen Indirect Cost: 1,110,000 Yen)
Research Abstract
To reveal effects of Streptococcus pneumoniae on the exacerbation of RSV-induced pneumonia, effects of formalin-inactivated the bacteria (SP) on RSV infection in mice were investigated.Single intranasal exposure to SP did not show any exacerbation of pneumonia in RSV-infected mice on day 5 post-infection, compared with a brominated flame retardant TBBPA. By three times exposure to SP, the levels of proinflammatory cytokines, such as TNF-α and IL-6, in bronchoalveolar lavage fluid were strongly suppressed rather than enhancement of inflammation in RSV-infected mice on day 1 post-infection. The tendency to alleviate pneumonia due to the SP-exposure was also found in histopathological analysis. Pulmonary viral titers were significantly decreased due to SP-exposure in RSV-infected mice compare with the control on day 5 post-infection. Analysis for the mechanism of action of our findings should contribute to establish novel approach for reduction of exacerbation of RSV-induced pneumonia.
Details 詳細情報について
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- CRID
- 1040282257278258816
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- Text Lang
- ja
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- Data Source
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- KAKEN
