Identification of chondroitin sulfate isotypes with adipocyte differentiation inhibitory activity, elucidation of their functions, and regulation of fat mass

About this project

Japan Grant Number
JP20K06411
Funding Program
Grants-in-Aid for Scientific Research
Funding organization
Japan Society for the Promotion of Science
Project/Area Number
20K06411
Research Category
Grant-in-Aid for Scientific Research (C)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Basic Section 42020:Veterinary medical science-related
Research Institution
  • Kyushu University
  • Tottori University
Project Period (FY)
2020-04-01 〜 2023-03-31
Project Status
Completed
Budget Amount*help
4,420,000 Yen (Direct Cost: 3,400,000 Yen Indirect Cost: 1,020,000 Yen)

Research Abstract

脂肪細胞分化抑制活性が最も高いCS種を同定し、その後、分化過程でのCSおよびその合成を担うChstの挙動を、細胞および生体レベルで解明する。さらには、Chstの発現量を、細胞および生体レベルで調節することで、生体の脂肪量の制御を試みる。これらから、脂肪細胞分化でのChstの機能を、細胞および生体レベルで明らかにする。

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