Establishment of novel therapeutic strategies against cancers via identification of neosubstrate of IMiDs

KAKEN

About This Project

Japan Grant Number
JP20K21617 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
20K21617
Research Category
Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Research Institution
  • Kyushu University
Project Period (FY)
2020-07-30 〜 2022-03-31
Project Status
Completed
Budget Amount*help
6,500,000 Yen (Direct Cost: 5,000,000 Yen Indirect Cost: 1,500,000 Yen)

Research Abstract

臨床的にIMiDsは骨髄腫治療において血小板減少を高頻度に生じ、治療中断の重要な原因である。我々は、IMiDsによる血小板減少の原因解明に取り組み、Aromatase(AROM)がその原因となるneo-substrateであることを見出した。本研究は、AROM分解メカニズム解明を進めると同時に、IMiDsによるAROM分解が閉経後乳癌治療へ応用可能か検討し、新規乳癌治療法開発につなげることを目的とする。

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