Novel Treatment for Medication-Related Osteonecrosis of the Jaw with Mucosal Closure Deficiency Using Stem Cell-Derived Mitochondria

About this project

Japan Grant Number
JP24K02634
Funding Program
Grants-in-Aid for Scientific Research
Funding organization
Japan Society for the Promotion of Science
Project/Area Number
24K02634
Research Category
Grant-in-Aid for Scientific Research (B)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Basic Section 57050:Prosthodontics-related
Research Institution
  • Kyushu University
Project Period (FY)
2024-04-01 〜 2028-03-31
Project Status
Granted
Budget Amount*help
18,330,000 Yen (Direct Cost: 14,100,000 Yen Indirect Cost: 4,230,000 Yen)

Research Abstract

本研究では3つの「問い」を解明する。すなわち、1)MRONJの病態の一つである口腔粘膜の閉鎖不全は上皮細胞のミトコンドリアの異常によるものか?2)MSCによる不良ミトコンドリアの交換がOECの局所的な異常性も改善し、MRONJの治療に寄与できるか? 3)細胞投与ではなく、ミトコンドリアを直接治療に生かすことができるか?である。

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