Impact of Gut Microbiota on Antibody-Mediated Rejection in a Rat Secondary Transplantation Model

KAKEN

About This Project

Japan Grant Number
JP25K11843 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
25K11843
Research Category
Grant-in-Aid for Scientific Research (C)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Basic Section 55010:General surgery and pediatric surgery-related
Research Institution
  • Kyushu University
Project Period (FY)
2025-04-01 〜 2029-03-31
Project Status
Granted
Budget Amount*help
4,680,000 Yen (Direct Cost: 3,600,000 Yen Indirect Cost: 1,080,000 Yen)

Research Abstract

本研究では、皮膚移植で感作したラットに腎移植を行う抗体拒絶モデルを用いる。また、申請者らが行ったP.g経口投与により腸内細菌叢の変化を引き起こす腸管ディスバイオシスモデルを利用し、DSAの産生及び抗体関連拒絶反応への影響を調べる。これらのメカニズムを解明し、プロバイオティクスやプレバイオティクスの投与による実践的な応用につなげる。

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