Design and Synthesis of Caged Compound with High Two-Photon Absorption Character in Near IR Region :Its Application to Physiological Experiments
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- Chitose Youhei
- Principal Investigator
- 九州大学
About this project
- Japan Grant Number
- JP21K20539
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 21K20539
- Research Category
- Grant-in-Aid for Research Activity Start-up
- Allocation Type
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- Multi-year Fund
- Review Section / Research Field
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- 0501:Physical chemistry, functional solid state chemistry, organic chemistry, polymers, organic materials, biomolecular chemistry, and related fields
- Research Institution
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- Kyushu University
- Hiroshima University
- Project Period (FY)
- 2021-08-30 〜 2023-03-31
- Project Status
- Completed
- Budget Amount*help
- 3,120,000 Yen (Direct Cost: 2,400,000 Yen Indirect Cost: 720,000 Yen)
Research Abstract
本研究では，理論計算によって高い近赤外2光子吸収能を有する光解離性保護基を設計し，合成を行う．有機溶媒中での光脱保護効率を確認したのち，保護基部位に十分な水溶性を有する置換基を導入することで細胞実験への応用を試みる．グルタミン酸や抗がん剤などの生物活性物質を保護したケージド化合物を合成し，生体内において，近赤外光を用いて活性物質の濃度上昇を時空間的に制御し，これまで未知であった活性発現機構の解明に貢献する．
Details 詳細情報について
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- CRID
- 1040571339785744128
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- Text Lang
- ja
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- Data Source
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- KAKEN