Mechanical stress response of senescent osteocytes: an intercellular communication between bone resident cells mediated by specific secreted factors.

KAKEN

About This Project

Japan Grant Number
JP22K09403 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
22K09403
Research Category
Grant-in-Aid for Scientific Research (C)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Basic Section 56020:Orthopedics-related
Research Institution
  • Kyushu University
Project Period (FY)
2022-04-01 〜 2025-03-31
Project Status
Granted
Budget Amount*help
4,160,000 Yen (Direct Cost: 3,200,000 Yen Indirect Cost: 960,000 Yen)

Research Abstract

本研究の概要は、力学的刺激に対して老化骨細胞が分泌する液性因子の、骨リモデリングにおける生理的・病理的意義を明らかにすることであり、老化骨細胞メカノトランスダクションの網羅的遺伝子発現解析に基づき特異的分泌因子を同定し、骨代謝細胞間クロストーク機序の解明を行う。本研究成果により、加齢に伴う骨脆弱化予防法および骨老化マーカー創出へ向けた研究基盤の確立を目指す。

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