急性肝障害における肝再生機構の多様性の解明

KAKEN

About This Project

Japan Grant Number
JP24K18977 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
24K18977
Research Category
Grant-in-Aid for Early-Career Scientists
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Basic Section 53010:Gastroenterology-related
Research Institution
  • Kyushu University
Project Period (FY)
2024-04-01 〜 2027-03-31
Project Status
Granted
Budget Amount*help
4,810,000 Yen (Direct Cost: 3,700,000 Yen Indirect Cost: 1,110,000 Yen)

Research Abstract

肝細胞の多方向性を示す形質転換の詳細を明らかにするために、① 各細胞集団のキャラクタライズ、② 阻害実験による各細胞集団の肝再生への寄与の確認、③ 異なる肝障害での再生機構の確認、④ 臨床検体を用いた各細胞集団、シグナルパスウェイの確認を行い、同定できた肝再生機構から治療標的となる候補分子を推定して、⑤ 急性肝不全の新規治療開発を目指す。

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