Development of Reversible Double-Layer Polymer Modification Technology to Break the Safety/Efficacy Trade-Off of Delivering Enzyme
About This Project
- Japan Grant Number
- JP23K28429 (JGN)
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding Organization
- Japan Society for the Promotion of Science
Kakenhi Information
- Project/Area Number
- 23K28429
- Research Category
- Grant-in-Aid for Scientific Research (B)
- Allocation Type
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- Multi-year Fund
- Single-year Grants
- Review Section / Research Field
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- Basic Section 90120:Biomaterials-related
- Research Institution
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- Kyushu University
- Project Period (FY)
- 2023-04-01 〜 2026-03-31
- Project Status
- Granted
- Budget Amount*help
- 13,520,000 Yen (Direct Cost: 10,400,000 Yen Indirect Cost: 3,120,000 Yen)
Research Abstract
This polymer delivery system can synchronize long circulation in blood, precise clearance and degradation by macrophage, and enzyme activation in tumor. The key points are to control hydrophilic-hydrophobic balance and number of modified polymers to enable (i) long blood circulation and macrophage-tropism together and (ii) degradation of enzyme before activation in macrophage.
Keywords
Details 詳細情報について
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- CRID
- 1040581301858371840
-
- Text Lang
- ja
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- Data Source
-
- KAKEN
