Elucidation of the novel RNA secondary structure induced by a small molecule

KAKEN

About This Project

Japan Grant Number
JP21K19050 (JGN)
Funding Program
Grants-in-Aid for Scientific Research
Funding Organization
Japan Society for the Promotion of Science

Kakenhi Information

Project/Area Number
21K19050
Research Category
Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Medium-sized Section 37:Biomolecular chemistry and related fields
Research Institution
  • Kyushu University
  • Osaka University
Project Period (FY)
2021-07-09 〜 2025-03-31
Project Status
Granted
Budget Amount*help
6,370,000 Yen (Direct Cost: 4,900,000 Yen Indirect Cost: 1,470,000 Yen)

Research Abstract

本研究は、低分子NA(Naphthyridine Azaquinolone)で誘起される新奇RNA立体構造の実証を目的とする。本研究の目的達成のために、NAと標的RNAとの結合評価、および、種々の構造解析手法を用いたNA-標的RNA複合体の立体構造解析を行う。さらに、NAで誘起される新奇RNA立体構造の、RNA編集反応における反応活性制御への応用を検討する。

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