Development of novel therapy for AML using BCL2 inhibitor

KAKEN

About this project

Japan Grant Number
JP23K07860
Funding Program
Grants-in-Aid for Scientific Research
Funding organization
Japan Society for the Promotion of Science
Project/Area Number
23K07860
Research Category
Grant-in-Aid for Scientific Research (C)
Allocation Type
  • Multi-year Fund
Review Section / Research Field
  • Basic Section 54010:Hematology and medical oncology-related
Research Institution
  • Kyushu University
Project Period (FY)
2023-04-01 〜 2026-03-31
Project Status
Granted
Budget Amount*help
4,680,000 Yen (Direct Cost: 3,600,000 Yen Indirect Cost: 1,080,000 Yen)

Research Abstract

本計画では、CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) / Cas9 (Crispr Associated protein 9) systemを用いた機能的スクリーニングをBCL2を標的とした新規AML治療薬Venetoclax, Azacitidineを用いて行い、抗白血病作用メカニズムを明らかとするとともに、耐性機構として働いている分子を同定することで、新たなAML治療法開発の基盤となるシーズを創出する。

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