Custom Synthesis of Hyaluronan/Chondroitin Sulfate Hybrid Oligosaccharides : For Future Medical Applications

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Hyaluronan and chondroitin sulfate sugar chains play important roles as major components of extracellular matrix. They are attractive molecules for biochemical research and are also used in pharmaceutical agents. However, details of the relationships between their oligosaccharide structures and functions are not known because of a lack of availability of model oligosaccharides with known structures. In order to, in the future, investigate their functions based on structure, we synthesized hybrid oligosaccharides by the in vitro transglycosylation reaction of hyaluronidase using various combinations of acceptors and donors. A total of 18 kinds of pyridylaminated hyaluronan/chondroitin sulfate hybrid oligosaccharides （from octasaccahride to dodecasaccharide）, which have not been found in nature, were synthesized.

弘前医学. 64(Suppl.), 2013, p.S53-S57

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  • 弘前医学

    弘前医学 64 (Supplement), S53-S57, 2013-04-02

    弘前大学大学院医学研究科・弘前医学会

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