Bibliographic Information
- Other Title
-
- リグニンスルホン酸による食後高血糖抑制作用
- リグニンスルホンサン ニ ヨル ショクゴ コウケットウ ヨクセイ サヨウ
Search this article
Description
Lignosulfonic acid is a waste lignin produced from the sulfite pulping of softwood. We investigated the effect of lignosulfonic acid on α-glucosidase and found that lignosulfonic acid produced a reversible and non-competitive inhibition of the enzyme activity. Moreover, in human colorectal adenocarcinoma cells, lignosulfonic acid inhibited 2-deoxyglucose uptake, while in vivo studies demonstrated a significant reduction in the blood glycemic response to sucrose or glucose ingestion in rats treated with lignosulfonic acid. Feces of rats fed a diet supplemented with 5% lignosulfonic acid had higher sugar content compared to those of rats fed a control diet. These results suggest that lignosulfonic acid suppresses the rise in blood glucose levels through inhibition of α-glucosidase activity and intestinal glucose absorption. Additionally, lignosulfonic acid suppressed increase of blood glucose level in diabetic KK-Ay mice. These results suggest that lignosulfonic acid may be useful as an anti-diabetes agent.
Journal
-
- Memoirs of the Muroran Institute of Technology
-
Memoirs of the Muroran Institute of Technology 66 11-15, 2017-03-24
室蘭工業大学
- Tweet
Details 詳細情報について
-
- CRID
- 1050001201680682880
-
- NII Article ID
- 120005983651
-
- NII Book ID
- AA11912609
-
- HANDLE
- 10258/00009179
-
- NDL BIB ID
- 028077252
-
- ISSN
- 13442708
-
- Text Lang
- ja
-
- Article Type
- departmental bulletin paper
-
- Data Source
-
- IRDB
- NDL
- CiNii Articles