<ORIGINAL REPORT>STUDIES ON LYMPHOID TISSUE DAMAGE WITH A TOXIC PHYTOHEMAGGLUTININ AND ITS SUBFRACTIONS IN MICE

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  • Studies on lymphoid tissue damage with a toxic phytohemagglutinin and its subfractions in mice
  • Studies on lymphoid tissue damage with

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PHAs prepared from red kidney beans in the laboratory were tested in hemagglutinating, blastogenic and toxic activities and found to be more potent in these activities than PHA-P (Difco). Especially, our PHAs showed prominent toxicity to mice. An intraperitoneal application of 2 mg of PHA (Bo) or PHA (Ba) was enough to kill adult mouse and caused severe damage in lymphoid tissues. The "conversion" of cellularity in the thymus and marked depression of lymphoid elements with intensive hemorrhage were observed histologically as signs of toxicity. PHAs were further investigated by CM-cellulose column chromatography. Toxic component could be separated from the fraction furnished with hemagglutinating activity or blastogenic activity.

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