Multiple Chromophobe Renal Cell Carcinoma : A Case Report

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  • Tsutsumi, Naofumi
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Soda, Takeshi
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Shimizu, Takashi
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Watanabe, Jun
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Yoshimura, Koji
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Kamba, Tomomi
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Kanematsu, Akihiro
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Nakamura, Eijiro
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Nishiyama, Hiroyuki
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Ito, Noriyuki
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Kamoto, Toshiyuki
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Ogawa, Osamu
    The Department of Urology, Kyoto University Graduate School of Medicine

Bibliographic Information

Other Title
  • 多発性嫌色素性腎細胞癌の1例
  • タハツセイ ケン シキソセイジンサイボウガン ノ 1レイ

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Abstract

A 46-year-old woman with gross hematuria was referred to our hospital with suspicion of bilateral renal cell carcinoma. Computed tomography (CT) showed multiple renal tumors with contrast enhancement and multiple lung nodules. Based on a diagnosis of bilateral multiple renal cell carcinoma with multiple lung metastases, a combination therapy with interferon-alpha (IFN-α) and 5-flurouracil (5-FU) was initiated. Six months later, all the renal and pulmonary lesions remained the same, and IFN-α alone was continued thereafter. One tumor in the right upper pole decreased in size during the next six years, while all the other lesions remained unchanged. Then the immunotherapy was discontinued on the basis of possibility that the tumors could be benign lesions. Three years later, the right upper renal tumor disappeared on CT, but, one of the left renal tumors showed progressive disease. The patient underwent left partial nephrectomy together with resection of neighboring small tumors. All the excised tumors were diagnosed as chromophobe renal cell carcinoma on histological examination. There has been no change with the remaining tumors for 1.5 years postoperatively.

Journal

  • Hinyokika Kiyo

    Hinyokika Kiyo 56 (6), 319-321, 2010-06

    泌尿器科紀要刊行会

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