A Case of Amyloidosis of the Ureter Caused by Primary Macroglobulinemia

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  • Miyazaki, Yu
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Kamba, Tomomi
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Shimizu, Yosuke
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Inoue, Takahiro
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Okubo, Kazutoshi
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Watanabe, Jun
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Yoshimura, Koji
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Kanematsu, Akihiro
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Nishiyama, Hiroyuki
    The Department of Urology, Kyoto University Graduate School of Medicine
  • Ogawa, Osamu
    The Department of Urology, Kyoto University Graduate School of Medicine

Bibliographic Information

Other Title
  • 原発性マクログロブリン血症による尿管アミロイドーシスの1例
  • ゲンパツセイ マクログロブリン ケッショウ ニ ヨル ニョウカン アミロイドーシス ノ 1レイ

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Abstract

A 78-year-old woman was referred to our hospital with chief complaint of colicky right flank pain. Computed tomography (CT) demonstrated right hydronephrosis and a wall thickening in the right ureteropelvic junction. Right nephroureterectomy was performed under a clinical diagnosis of invasive ureteral cancer. Histological examination revealed immunoglobulin light chain (AL) amyloidosis of the ureter. Although amyloid deposition seemed to be localized to the ureter alone, bone marrow biopsy revealed primary macroglobulinemia. After 23 months, no signs or symptoms suggesting the progression of amyloidosis or macroglobulinemia have been pointed out. AL amyloidosis arising secondarily to plasma cell disorder is called immunocytic amyloidosis. In general, immunocytic amyloidosis accompanies deposition of the amyloid protein to various organs of the whole body, and causes multiple clinical symptoms related to amyloid deposition. Even though the clinical manifestation indicates the localized disease like the presented case, close examination of immunocytic amyloidosis is important.

Journal

  • Hinyokika Kiyo

    Hinyokika Kiyo 57 (4), 185-188, 2011-04

    泌尿器科紀要刊行会

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