SYNERGISTIC ANTIBACTERIAL ACTIVITY OF ANTIBIOTICS AS WELL AS OTHER COMPOUNDS, ESPECIALLY MECILLINAM, CLAVULANIC ACID, FOSFOMYCIN AND FOSFONOPEPTIDE

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  • Uete, Teteuo
    The Department of Clinical Investigation, Tazuke Kofukai Medical Research Institute Kitano Hospital, Osaka

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Other Title
  • (特集：PIVMECILLINAMによる尿路感染症の治療) 抗生物質併用による抗菌力の相乗的増強 - とくにメシリナム,クラブラニック酸,フォスフォマイシン,フォスフォノペプチドの臨床的意義 -
  • 抗生物質併用による抗菌力の相乗的増強--とくにメシリナム,クラブラニック酸,フォスフォマイシン,フォスフォノペプチドの臨床的意義
  • コウセイ ブッシツ ヘイヨウ ニヨル コウキンリョク ノ ソウジョウテキ ゾウ

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In case of mecillinam, its mode of action seems to be different from that of other penicillins and its synergistic antibacterial activity with other beta-Iactams has been reported by many papers. Recently the synergistic antibacterial activity between beta-Iactams and clavulanic acid as well as CP45899 (beta-Iactamase inhibitors), and fosfomycin as well as phosphonopeptide and various antibiotics have been reported. It seems that the combined use of these antibiotics as well as such compounds will have the advantage also in clinical use from the viewpoint of efficacy and safety.

Journal

  • Hinyokika Kiyo

    Hinyokika Kiyo 26 (特集号), 17-26, 1980-08

    京都大学医学部泌尿器科学教室

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