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Distorted antibody repertoire developed in the absence of pre-B cell receptor formation
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Description
The pre-B cell receptor (pre-BCR), consisting of the μ heavy chain (μHC) and the surrogate light chain (SLC, Vpre-B and λ5), plays important roles during B cell development. The formation of the pre-BCR, which enables the nascent immunoglobulin HC to associate with the SLC, is considered a prerequisite for B cell development. However, a significant number of peripheral mature (leaky) B cells exist in SLC-deficient mice. These leaky B cells develop in the absence of pre-BCR and do not undergo the pre-BCR checkpoint. The antibody repertoires of leaky B cells thus reflect the absence of pre-BCR function. To investigate how the absence of the pre-BCR is circumvented by these leaky-B cells and examine the effect of the pre-BCR checkpoint on the antibody system, we analyzed the antibody repertoires of λ5-deficient (λ5
Journal
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- Biochemical and biophysical research communications
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Biochemical and biophysical research communications 495 (1), 1411-1417, 2018-01
Elsevier
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Keywords
Details 詳細情報について
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- CRID
- 1050001202543042560
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- NII Book ID
- AA00564395
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- HANDLE
- 2241/00151196
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- ISSN
- 0006291X
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- PubMed
- 29191653
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- Crossref
- KAKEN
- OpenAIRE